ER 50891( —— )

Catalog No. M33848 CAS No. 187400-85-7

ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast differentiation induced by bone morphogenetic protein 2.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
2MG	248	Get Quote
5MG	416	Get Quote
10MG	549	Get Quote
25MG	853	Get Quote
50MG	1159	Get Quote
100MG	1512	Get Quote
200MG	2043	Get Quote
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Biological Information

Product Name

ER 50891
Note

Research use only, not for human use.
Brief Description

ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast differentiation induced by bone morphogenetic protein 2.
Description

ER-50891 is a potent antagonist of retinoic acid receptor α(RARα). ER-50891 significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

Retinoid Receptor
Recptor

Retinoid Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

187400-85-7
Formula Weight

432.51
Molecular Formula

C29H24N2O2
Purity

>98% (HPLC)
Solubility

——
SMILES

C(C)(C)C=1C2=C(C(=CC(=N2)C=3NC(=CC3)C4=CC=C(C(O)=O)C=C4)C5=CC=CC=C5)C=CC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Batran RZ, et al. New quinolone derivatives as neuropeptide S receptor antagonists: Design, synthesis, homology modeling, dynamic simulations and modulation of Gq/Gs signaling pathways. Bioorg Chem. 2021;111:104817.?

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